Custom Peptides
Cayman Chemical 11-hydroxy EtIocholnolon 10mg
A metabolite of hydrocortisone; fecal levels are increased in response to environmental stress in giraffes and plains zebras
Cayman Chemical OSILODROSTAT 10MG
An aldosterone synthase inhibitor; selective for human aldosterone synthase over rat aldosterone synthase (IC50 = 160 nM); inhibits increases in plasma aldosterone levels induced by angiotensin II or ACTH in rats (ED50s = 0.6 and 1.1 mg/kg, respectively); reduces mean arterial pressure and prolongs survival in rats expressing human renin and angiotensinogen, a double-transgenic model of angiotensin II-dependent hypertension, in a dose-dependent manner
Cayman Chemical 1 2DIoleoylsnglycero3PA 10mg
A phospholipid; has been used in the generation of micelles, liposomes, and other artificial membranes
Cayman Chemical Guafensn 10mg
An analytical reference standard categorized as an expectorant; intended for use in analytical forensic applications
Cayman Chemical 4AmInomethyl4 5 8trImeth 10mg
A bifunctional photoreactive agent for crosslinking nucleic acids; intercalates into double-stranded regions in DNA or RNA and, upon UV irradiation, forms covalent adducts with pyrimidine bases; used to study different types of RNA from diverse organisms, including viruses
Cayman Chemical N N-DIphenthylurea 10mg
A bacterial metabolite with diverse biological activities; inhibits Streptomyces chitin synthase 1 (IC50 = 14 UG/ml); active against C. neoformans and R. solani (MIC = 50 UG/ml for both); enhances insulin-induced adipocyte differentiation in 3T3-L1 and C3H/10T1/2 cells at 30 and 100 µM
Cayman Chemical ncrox-5methnsulfonate 10mg
A cell permeable inhibitor of necrosis that also demonstrates strong mitochondrial reactive oxygen species and ONOO- scavenging activity; localizes in mitochondria, selectively blocking oxidative stress-induced necrotic cell death (0.1 μM necrox-5 inhibited ~50% cell death in H9C2 cells exposed to 400 μM t-BHP)
Cayman Chemical 4-fluoro PV9hydrochlorIde 10mg
Differs from PV9 by having a fluorine atom at the four, or para, position of the phenyl group
Cayman Chemical Ro 106-9920 10mg
A small molecule inhibitor of NF-κB-dependent expression of TNF-α, IL-1β, and IL-6 (IC50 50 = 2.3 µM)
Cayman Chemical EndosIdIn 2 10mg
A cell-permeable inhibitor of exocytosis and endosomal recycling in plant and mammalian cells; binds the EXO70 subunit of the exocyst complex (Kd = 253 μM, EXO70A1); disrupts protein trafficking between the endosome and plasma membrane; enhances trafficking to the vacuole for degradation; inhibits recycling of endocytosed transferrin in HeLa cells
Cayman Chemical Z-GUGgulsteron 10mg
A competitive antagonist of farnesoid X receptor (IC50 = 17 µM ) that lowers LDL cholesterol and triglyceride levels in rodents fed a high cholesterol diet; demonstrates antitumor-promoting effects in human multiple myeloma and DU145 human prostate cancer cells
Cayman Chemical Losartn CarboxylIc AcId 10mg
An AT1b receptor antagonist and active metabolite of losartan; an antagonist of AT1b (Kis = 0.67 nM in COS-7 cells expressing the human receptor); selective for AT1b over AT2 (Ki = >10,000 nM in COS-7 cells expressing the human receptor); reduces U-44619-induced aggregation of platelets in isolated human platelet-rich plasma at 50 µM; reduces MAP in water-deprived rats at 1 mg/kg
Cayman Chemical 1H1ethyl Cndesartn CIlexe 10mg
A potential impurity found in bulk preparations of candesartan cilexetil; a degradation product formed by thermal, photolytic, oxidative, or hydrolytic stress during storage